Molecular Formula | C22H26N4O3 |
Molar Mass | 394.47 |
Density | 1.30 |
Melting Point | 143-145°C |
Solubility | DMSO 79 mg/mL Water <1 mg/mL Ethanol 79 mg/mL |
Appearance | powder |
Color | white to tan |
pKa | 14.18±0.10(Predicted) |
Storage Condition | Keep in dark place,Inert atmosphere,2-8°C |
MDL | MFCD19690947 |
Use | A highly selective H ,K -ATPase inhibitor that is more potent in acidic conditions. |
In vitro study | PF-03716556 is a potent, selective acid-Pump-resistant antagonist that inhibits porcine H in ion-permeation and ion-dense assays |
In vivo study | PF-03716556 inhibits gastric acid secretion in rat and dog animal models. PF-03716556 has a long-lasting effect, with a maximum effect of 30 minutes in a single dose, and there is no obvious signal of resistance after 5 consecutive days of injection. |
WGK Germany | 3 |
Biological activity | PF-3716556 is an effective and selective P-CAB potassium ion competitive acid inhibitor. In ion permeation and ion intensive detection, it inhibits pig H ,K -ATPase activity, inhibits gastric acid secretion, has no effect on Na ,K -ATPas, and is used to treat gastroesophageal reflux disease. |
Target | Value |
H+/K+-ATPase | ~6.5(pIC50) |